Discoveries in gene-environment interactions that influence CVD, lipid traits, obesity, diabetes, and hypertension appear to be able to influence gene therapy.
Authors: Moataz Dowaidar
DOI: 10.87349/JBUPT/27904
Page No: 23-47
Abstract
In a relatively short amount of time, significant progress has been made in discovering geneenvironment interactions that influence CVD, lipid traits, obesity, diabetes, and hypertension. These correlations appear to change genetic vulnerability, which may help researchers better understand the genetic processes that influence CVD development in the future. In order to advance the field, further research is required to confirm initial comparisons, identify the biological processes by which environmental influences modify genetic risk, and investigate strategies that use this knowledge to influence clinical genetic therapy outcomes. The leading cause of morbidity and death in the world is cardiovascular disease (CVD). 1 The majority of CVD cases are caused by modifiable risk factors including diabetes, asthma, obesity, dyslipidemia, smoking, lifestyle factors, psychosocial stressors, alcohol intake levels, and physical inactivity, which account for more than 90% of MI cases and more than 80% of stroke cases worldwide. 2 and 3 Despite the fact that CVD prevalence is decreasing in highincome countries, it is rising in many low-and middle-income countries as a result of rapid lifestyle changes, growth, and urbanization. Such noncommunicable cardiometabolic disorders, such as obesity, hypertension, and diabetes, have also increased as a result of these shifts. 4 and 5 Several ethnic groups in Canada, including South Asians, Aboriginals, Chinese, and Afro-Caribbeans, are at risk of contracting cardiometabolic diseases. 6 To reduce global CVD pressure, individual and population-level interventions aimed at improving modifiable cardiovascular risk factors are needed.
